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Blood sugar level

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The fluctuation of blood sugar (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day with three meals. One of the effects of a sugar-rich vs a starch-rich meal is highlighted.[1]

The blood sugar level, blood sugar concentration, or blood glucose level is the concentration of glucose present in the blood of humans and other animals. Glucose is a simple sugar and approximately 4 grams of glucose are present in the blood of a 70-kilogram (150 lb) human at all times.[2] The body tightly regulates blood glucose levels as a part of metabolic homeostasis.[2] Glucose is stored in skeletal muscle and liver cells in the form of glycogen;[2] in fasted individuals, blood glucose is maintained at a constant level at the expense of glycogen stores in the liver and skeletal muscle.[2]

In humans, a blood glucose level of four grams, or about a teaspoon, is critical for normal function in a number of tissues, and the human brain consumes approximately 60% of blood glucose in fasted, sedentary individuals.[2] A persistent elevation in blood glucose leads to glucose toxicity, which contributes to cell dysfunction and the pathology grouped together as complications of diabetes.[2] Glucose can be transported from the intestines or liver to other tissues in the body via the bloodstream.[2] Cellular glucose uptake is primarily regulated by insulin, a hormone produced in the pancreas.[2]

Glucose levels are usually lowest in the morning, before the first meal of the day, and rise after meals for an hour or two by a few millimoles. Blood sugar levels outside the normal range may be an indicator of a medical condition. A persistently high level is referred to as hyperglycemia; low levels are referred to as hypoglycemia. Diabetes mellitus is characterized by persistent hyperglycemia from any of several causes, and is the most prominent disease related to failure of blood sugar regulation. There are different methods of testing and measuring blood sugar levels.

The intake of alcohol causes an initial surge in blood sugar, and later tends to cause levels to fall. Also, certain drugs can increase or decrease glucose levels.[3]

Contents

Unitsablazeaboutalaska com 3[edit]

ablazeaboutalaska com 3The international standard way of measuring blood glucose levels is in terms of a molar concentration, measured in mmol/L (millimoles per litre; or millimolar, abbreviated mM). In the United States, Germany and other countries mass concentration is measured in mg/dL (milligrams per decilitre).[4]

Since the molecular weight of glucose C6H12O6 is 180, the difference between the two units is a factor of 18, so that 1 mmol/L of glucose is equivalent to 18 mg/dL.[5]

ablazeaboutalaska com 3Normal valuesablazeaboutalaska com 3[editablazeaboutalaska com 3]

Humans[edit]

ablazeaboutalaska com 3Normal value ranges may vary slightly among different laboratories. Many factors affect a person''s homeostatic mechanism of blood sugar regulation (known as glucose homeostasis), when operating normally, restores the blood sugar level to a narrow range of about 4.4 to 6.1 mmol/L (79 to 110 mg/dL) (as measured by a fasting blood glucose test).[6]

The normal blood glucose level (tested while fasting) for non-diabetics, should be between 3.9 and 7.1 mmol/L (70 to 130 mg/dL). The global mean fasting plasma blood glucose level in humans is about 5.5 mmol/L (100 mg/dL);[7][5] however, this level fluctuates throughout the day. Blood sugar levels for those without diabetes and who are not fasting should be below 6.9 mmol/L (125 mg/dL).[8] The blood glucose target range for diabetics, according to the American Diabetes Association, should be 5.0–7.2 mmol/l (90–130 mg/dL) before meals, and less than 10 mmol/L (180 mg/dL) after meals (as measured by a blood glucose monitor).[9]

Despite widely variable intervals between meals or the occasional consumption of meals with a substantial carbohydrate load, human blood glucose levels tend to remain within the normal range. However, shortly after eating, the blood glucose level may rise, in non-diabetics, temporarily up to 7.8 mmol/L (140 mg/dL) or slightly more. For people with diabetes maintaining '', the American Diabetes Association recommends a post-meal glucose level of less than 10 mmol/L (180 mg/dL) and a fasting plasma glucose of 3.9 to 7.2 mmol/L (70–130 mg/dL).[10]

The actual amount of glucose in the blood and body fluids is very small. In a healthy adult male of 75 kg with a blood volume of 5 liters, a blood glucose level of 5.5 mmol/L (100 mg/dL) amounts to 5g, equivalent to about a teaspoonful of sugar.[11] Part of the reason why this amount is so small is that, to maintain an influx of glucose into cells, enzymes modify glucose by adding phosphate or other groups to it.

ablazeaboutalaska com 3Other animals[edit]

ablazeaboutalaska com 3In general, ranges of blood sugar in common domestic ruminants are lower than in many monogastric mammals.[12] However this generalization does not extend to wild ruminants or camelids. For serum glucose in mg/dL, reference ranges of 42 to 75 for cows, 44 to 81 for sheep, and 48 to 76 for goats, but 61 to 124 for cats; 62 to 108 for dogs, 62 to 114 for horses, 66 to 116 for pigs, 75 to 155 for rabbits, and 90 to 140 for llamas have been reported.[13] A 90 percent reference interval for serum glucose of 26 to 181 mg/dL has been reported for captured mountain goats (Oreamnos americanus), where no effects of the pursuit and capture on measured levels were evident.[14] For beluga whales, the 25–75 percent range for serum glucose has been estimated to be 94 to 115 mg/dL.[15] For the white rhinoceros, one study has indicated that the 95 percent range is 28 to 140 mg/dL.[16] For harp seals, a serum glucose range of 4.9 to 12.1 mmol/L [i.e. 88 to 218 mg/dL] has been reported; for hooded seals, a range of 7.5 to 15.7 mmol/L [i.e. about 135 to 283 mg/dL] has been reported.[17]

ablazeaboutalaska com 3Regulationablazeaboutalaska com 3[edit]

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Main article: Blood sugar regulation

The body''s organs. This is especially the case for those organs that are metabolically active or that require a constant, regulated supply of blood sugar (the liver and brain are examples). In healthy individuals, blood glucose-regulating mechanisms are generally quite effective, and symptomatic hypoglycemia is generally found only in diabetics using insulin or other pharmacological treatment, and in starvation or severe malnutrition or malabsorption (of various causes), and conditions such as anorexia[ablazeaboutalaska com 3dubious discuss]. Hypoglycemic episodes can vary greatly between persons and from time to time, both in severity and swiftness of onset. For severe cases, prompt medical assistance is essential, as damage to brain and other tissues and even death will result from sufficiently low blood-glucose levels.

ablazeaboutalaska com 3Glucose measurementablazeaboutalaska com 3ablazeaboutalaska com 3[edit]

Further information: Blood glucose monitoring and Glucose meter

ablazeaboutalaska com 3Sample source[editablazeaboutalaska com 3]

ablazeaboutalaska com 3Glucose testing in a fasting individual, show comparable levels of glucose in arterial, venous, and capillary blood. But following meals, capillary and arterial blood glucose levels can be significantly higher than venous levels. Although these differences vary widely, one study found that following the consumption of 50 grams of glucose, ""[24][25][26]

Sample type[edit]

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Glucose is measured in whole blood, plasma or serum. Historically, blood glucose values were given in terms of whole blood, but most laboratories now measure and report plasma or serum glucose levels. Because red blood cells (erythrocytes) have a higher concentration of protein (e.g., hemoglobin) than serum, serum has a higher water content and consequently more dissolved glucose than does whole blood. To convert from whole-blood glucose, multiplication by 1.14[27] has been shown to generally give the serum/plasma level

To prevent contamination of the sample with intravenous fluids, particular care should be given to drawing blood samples from the arm opposite the one in which an intravenous line is inserted. Alternatively, blood can be drawn from the same arm with an IV line after the IV has been turned off for at least 5 minutes, and the arm has been elevated to drain infused fluids away from the vein. Inattention can lead to large errors, since as little as 10% contamination with a 5% glucose solution (D5W) will elevate glucose in a sample by 500 mg/dL or more. The actual concentration of glucose in blood is very low, even in the hyperglycemic.

ablazeaboutalaska com 3Measurement techniques[edit]

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ablazeaboutalaska com 3Two major methods have been used to measure glucose. The first, still in use in some places, is a chemical method exploiting the nonspecific reducing property of glucose in a reaction with an indicator substance that changes color when reduced. Since other blood compounds also have reducing properties (e.g., urea, which can be abnormally high in uremic patients), this technique can produce erroneous readings in some situations (5–15 mg/dL has been reported). The more recent technique, using enzymes specific to glucose, is less susceptible to this kind of error. The two most common employed enzymes are glucose oxidase and hexokinase.[28] Average blood glucose concentrations can also be measured. This method measures the level of glycated hemoglobin, which is representative of the average blood glucose levels over the last, approximately, 120 days.[28]

ablazeaboutalaska com 3In either case, the chemical system is commonly contained on a test strip which is inserted into a meter, and then has a blood sample applied. Test-strip shapes and their exact chemical composition vary between meter systems and cannot be interchanged. Formerly, some test strips were read (after timing and wiping away the blood sample) by visual comparison against a color chart printed on the vial label. Strips of this type are still used for urine glucose readings, but for blood glucose levels they are obsolete. Their error rates were, in any case, much higher. Errors when using test strips were often caused by the age of the strip or exposure to high temperatures or humidity.[29] More precise blood glucose measurements are performed in a medical laboratory, using hexokinase, glucose oxidase, or glucose dehydrogenase enzymes.

ablazeaboutalaska com 3Urine glucose readings, however taken, are much less useful. In properly functioning kidneys, glucose does not appear in urine until the renal threshold for glucose has been exceeded. This is substantially above any normal glucose level, and is evidence of an existing severe hyperglycemic condition. However, as urine is stored in the bladder, any glucose in it might have been produced at any time since the last time the bladder was emptied. Since metabolic conditions change rapidly, as a result of any of several factors, this is delayed news and gives no warning of a developing condition. Blood glucose monitoring is far preferable, both clinically and for home monitoring by patients. Healthy urine glucose levels were first standardized and published in 1965[30] by Hans Renschler.

I. Chemical methods
A. Oxidation-reduction reaction
ablazeaboutalaska com 3ablazeaboutalaska com 3 G l u c o s e + A l k a l i n e   c o p p e r   t a r t a r a t e R e d u c t i o n C u p r o u s   o x i d e {\displaystyle \mathrm {Glucose} +\mathrm {Alkaline\ copper\ tartarate} {\xrightarrow {\mathrm {Reduction} }}\mathrm {Cuprous\ oxide} }
1. Alkaline copper reduction
Folin-Wu method C u 2 + + P h o s p h o m o l y b d i c   a c i d O x i d a t i o n P h o s p h o m o l y b d e n u m   o x i d e {\displaystyle \mathrm {Cu} ^{2+}+\mathrm {Phosphomolybdic\ acid} {\xrightarrow {\mathrm {Oxidation} }}\mathrm {Phosphomolybdenum\ oxide} } Blue end-product
Benedict''s base which is emerald green in color.
  • This is the most specific method, but the reagent used is toxic.
  • Anthrone (phenols) method
    • Forms hydroxymethyl furfural in hot acetic acid
    II. Enzymatic methods
    A. Glucose oxidase
    G l u c o s e + O 2 O x i d a t i o n g l u c o s e   o x i d a s e D-glucono-1,5-lactone + H 2 O 2 {\displaystyle \mathrm {Glucose} +\mathrm {O} _{2}{\xrightarrow[{\mathrm {Oxidation} }]{\mathrm {glucose\ oxidase} }}{\textrm {D-glucono-1,5-lactone}}+\mathrm {H_{2}O_{2}} }
    Saifer–Gerstenfeld method ablazeaboutalaska com 3 H 2 O 2 + O -dianisidine O x i d a t i o n p e r o x i d a s e H 2 O + o x i d i z e d   c h r o m o g e n {\displaystyle \mathrm {H_{2}O_{2}} +{\textit {O}}{\text{-dianisidine}}{\xrightarrow[{\mathrm {Oxidation} }]{\mathrm {peroxidase} }}\mathrm {H_{2}O} +\mathrm {oxidized\ chromogen} } Inhibited by reducing substances like BUA, bilirubin, glutathione, ascorbic acid.
    Trinder method
    Kodak Ektachem
    • A dry chemistry method.
    • Uses spectrophotometry to measure the intensity of color through a lower transparent film.
    Glucometer
    • Home monitoring blood glucose assay method.
    • Uses a strip impregnated with a glucose oxidase reagent.
    B. Hexokinase

    ablazeaboutalaska com 3 G l u c o s e + A T P P h o s p h o r y l a t i o n H e x o k i n a s e + M g 2 + G-6PO 4 + A D P G-6PO 4 + N A D P O x i d a t i o n G-6PD 6-Phosphogluconate + N A D P H + H + {\displaystyle {\begin{alignedat}{2}&\mathrm {Glucose} +\mathrm {ATP} {\xrightarrow[{\mathrm {Phosphorylation} }]{\mathrm {Hexokinase} +\mathrm {Mg} ^{2+}}}{\textrm {G-6PO}}_{4}+\mathrm {ADP} \\&{\textrm {G-6PO}}_{4}+\mathrm {NADP} {\xrightarrow[{\mathrm {Oxidation} }]{\textrm {G-6PD}}}{\textrm {6-Phosphogluconate}}+\mathrm {NADPH} +\mathrm {H} ^{+}\\\end{alignedat}}}

    • NADP as cofactor.
    • NADPH (reduced product) is measured in 340 nm.
    • More specific than glucose oxidase method due to G-6PO4, which inhibits interfering substances except when sample is hemolyzed.

    Clinical correlation[editablazeaboutalaska com 3]

    The fasting blood glucose level, which is measured after a fast of 8 hours, is the most commonly used indication of overall glucose homeostasis, largely because disturbing events such as food intake are avoided. Conditions affecting glucose levels are shown in the table below. Abnormalities in these test results are due to problems in the multiple control mechanism of glucose regulation.

    The metabolic response to a carbohydrate challenge is conveniently assessed by a postprandial glucose level drawn 2 hours after a meal or a glucose load. In addition, the glucose tolerance test, consisting of several timed measurements after a standardized amount of oral glucose intake, is used to aid in the diagnosis of diabetes.

    ablazeaboutalaska com 3Error rates for blood glucose measurements systems vary, depending on laboratories, and on the methods used. Colorimetry techniques can be biased by color changes in test strips (from airborne or finger borne contamination, perhaps) or interference (e.g., tinting contaminants) with light source or the light sensor. Electrical techniques are less susceptible to these errors, though not to others. In home use, the most important issue is not accuracy, but trend. Thus if a meter / test strip system is consistently wrong by 10%, there will be little consequence, as long as changes (e.g., due to exercise or medication adjustments) are properly tracked. In the US, home use blood test meters must be approved by the federal Food and Drug Administration before they can be sold.

    Finally, there are several influences on blood glucose level aside from food intake. Infection, for instance, tends to change blood glucose levels, as does stress either physical or psychological. Exercise, especially if prolonged or long after the most recent meal, will have an effect as well. In the typical person, maintenance of blood glucose at near constant levels will nevertheless be quite effective.[clarification needed]

    Causes of abnormal glucose levels
    Persistent hyperglycemia Transient hyperglycemia Persistent hypoglycemia Transient hypoglycemia
    Reference range, fasting blood glucose (FBG): 70–110 mg/dL
    Diabetes mellitus Pheochromocytoma Insulinoma Acute alcohol ingestion
    Adrenal cortical hyperactivity Cushing''s disease Drugs: salicylates, antituberculosis agents
    Hyperthyroidism Acute stress reaction Hypopituitarism Severe liver disease
    Acromegaly Shock Galactosemia Several glycogen storage diseases
    Obesity Convulsions Ectopic insulin production from tumors Hereditary fructose intolerance

    ablazeaboutalaska com 3See also[edit]

    References[editablazeaboutalaska com 3]

    1. ^ ablazeaboutalaska com 3Daly ME, Vale C, Walker M, Littlefield A, Alberti KG, Mathers JC (June 1998). "" (PDF). The American Journal of Clinical Nutrition. 67 (6): 1186–96. doi:10.1093/ajcn/67.6.1186. PMID 9625092.
    2. ^ a b c d e f g h Wasserman DH (January 2009). "". American Journal of Physiology. Endocrinology and Metabolism. 296 (1): E11–21. doi:10.1152/ajpendo.90563.2008. PMC ablazeaboutalaska com 32636990. PMID 18840763.
    3. ^ ablazeaboutalaska com 3Walker, Rosemary and Rodgers, Jill (2006) Type 2 Diabetes – Your Questions Answered. Dorling Kindersley. ISBN 1-74033-550-3.
    4. ^ Diabetes FAQs – Blood Glucose Measurement Units – Abbott Diabetes Care
    5. ^ a b What are mg/dl and mmol/l? How to convert? Glucose? Cholesterol? Advameg, Inc.
    6. ^ "". Clinical Diabetes. 18 (2). 2000.
    7. ^ Danaei, G (2 July 2011). "". The Lancet. 378 (9785): 31–40. doi:10.1016/S0140-6736(11)60679-X. PMID 21705069.
    8. ^ ablazeaboutalaska com 3Glucose test – blood. NIH – National Institutes of Health.
    9. ^ Davidson NK, Moreland P (26 July 2011). "". Mayo Clinic. Archived from the original on 14 May 2013.
    10. ^ ablazeaboutalaska com 3American Diabetes Association (January 2006). "". Diabetes Care. 29 Suppl 1 (Supplement 1): S4–42. PMID 16373931. Standards of Medical Care – Table 6 and Table 7, Correlation between A1C level and Mean Plasma Glucose Levels on Multiple Testing over 2–3 months
    11. ^ ablazeaboutalaska com 3USDA National Nutrient Database for Standard Reference, Release 22 (2009)
    12. ablazeaboutalaska com 3^ Eiler H (2004). "". In Reese WO (ed.). Dukes''mw-data-after-content'>

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